Synthesis, Characterization and Biochemical assessment of 1,7 diphenyl heptanoids

Abstract: In recent years, there has been a surge in interest in using natural products to cure diseases. Turmeric's bioactive pigment, curcumin, has a wide range of applications in this sense. Curcumin, its analogues, and metal complexes have all been investigated extensively for biological activities such as antimicrobial, anti-inflammatory, antioxidant, and anticarcinogenic. A variety of compounds with structural similarities to curcuminoids have recently been synthesised, and their biological activities have been investigated. The synthesis and characterization of curcuminoid analogues with non substituted phenyl rings, dimethoxy substituted phenyl rings, and 1,2,3 trihydroxy substituted phenyl rings were discussed in this article. IR, 13C NMR, 1H NMR, and mass spectrum are used to characterise the samples. In vitro cytotoxic experiments against DLA cells (Daltons Lymphoma Ascites) were carried out using the Trypan blue exclusion process, and antimicrobial studies were carried out using the Kirby Bauer method. Antioxidant tests have also been conducted.

Keywords: Curcumin analogues, antioxidant, antimicrobial, cytotoxicity, 1,7 diphenyl heptanoids