SYNTHESIS CHARCTERIZATION AND ANTIMICROBILOLOGICAL ACTIVITY OF 4-THIAZOLIDINONE DERIVATIVES WITH FURAN AND PYRIDINE MOEITIES

Abstract: Isoniazid (1) on reaction with 5-arylfuran-2-carboxaldehydes (2a-e) yield N'-((5-Arylfuran-2-yl) methylene) isonicotinohydrazide (3a-e). Post reaction of these hydrazones (3a-e) with mercapto acetic acid afforded N-(4-oxo-2-(5-Arylfuran-2-yl) thiazolidin-3-yl) isonicotinamide (4a-e). Such 4-thiazolidinone derivatives were then treated with phenyl sulphonamide diazonium chloride yielded the compounds (N-(2-(5-arylfuran-2-yl)-4-oxo-5-(2-(4-sulfamoylphenyl) hydrazono) thiazolidin-3-yl) isonicotinamide (5a-e). The structures of these series of heterocycles were assigned by analytical and spectral feature. All the were also evaluated for their antibacterial and antifungal activities.

Keywords: Isoniazid, Schiff base, thiazolidine, diazonium salt, spectroscopy antibacterial and antifungal activities