NOVEL SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF COMPLEXES OF Mn(II), Ni(II) AND Cu(II) WITH 4-HYDROXY ACETOPHENONE THIOSEMICARBAZONE

Abstract: A series of novel 4-Hydroxyacetothiosemicarbazones complexes with three transition metal i.e. Mn(II), Ni(II) and Cu(II) having the general composition [Mn(4HAT)2Cl2], [Ni(4HAT)2Cl2] and [Cu(4HAT)2Cl2]{where 4HAT= 4-Hydroxyacetophenone thiosemicarbazones, have been synthesized by the reaction of thiosemicarbazide with 4-Hydroxyacetophenone by conventional heating as well as microwave irradiations method followed by complexation with transition metals. The synthesized compounds have been characterised by elemental analysis, melting point determination, FTIR, UV-visible spectral analysis. The synthesized ligands and their new metal complexes have been screened in vitro for antibacterial activity against Escherichia coli, Staphylococcus aureus and Bascillus subtilis bacteria.

Keywords: Thiosemicarbazones, Microwave irradiation, Transition metal complexes.